For Dental Professionals

Implant ProCare was developed by Dr. Kyle McGill, DDS, in clinical practice — not adapted from a general-market rinse. If you place or maintain implants, here's what you need to evaluate it.

The clinical problem it addresses

Home-care compliance in implant patients is a recurring frustration. Patients are commonly sent home with a chlorhexidine prescription that isn't appropriate for indefinite daily use and that many patients abandon over staining and taste alteration. Or they end up putting a little mouthwash into the water flosser reservoir — a ready-to-use rinse diluted by an unspecified amount of water, with no defined concentration at the point of use. Neither is a good long-term answer for a patient who will have that restoration for decades.

Implant ProCare is a concentrate specified for water flosser reservoirs, so the active is delivered by irrigation into the emergence profile and sulcus rather than only swished across occlusal and buccal surfaces.

Formulation

Why each ingredient is in the formula

Cetylpyridinium chloride — 0.1% as sold, 0.05% at point of use. The active. A quaternary ammonium compound with a long record in oral rinses: it carries a positive charge, which draws it to the negatively charged surfaces of oral bacteria and to the surfaces where biofilm forms, and gives it substantivity. Helps control plaque that leads to gingivitis.

Zinc citrate — 0.40% / 0.20%. Zinc salts are a long-standing companion to CPC in oral rinse formulation, and zinc's effect on volatile sulfur compounds is well characterized. Included on that formulation history rather than as a second active.

Xylitol — 4.00% / 2.00%. Non-fermentable polyol. Not metabolized to acid by oral bacteria, and it carries the sweetening load so no fermentable sugar enters the formula.

Hypromellose (HPMC) — 0.10% / 0.05%. Viscosity modifier. Antimicrobial benefit in the oral cavity depends on the active remaining at the site of action rather than being cleared straight away by saliva; HPMC is a well-characterized mucoadhesive excipient used in oromucosal delivery to extend retention, and it was selected here for that reason. A low-foaming formula was specified alongside it, on the reasoning that foam is a cosmetic expectation rather than a functional one in a product delivered by irrigation.

Directions as supplied to patients

Dilute 1:1 with water. Use 20 mL of diluted solution in a water flosser reservoir at low-to-medium pressure, tracing around each implant, once or twice daily or as directed. Spit out; do not swallow. Adults and children 12 and over; under 12 consult a dentist or doctor.

Ingredient literature

The studies below examine the individual ingredients used in Implant ProCare. They were conducted on other formulations, at other concentrations, and are provided as scientific background on those ingredients.

Implant ProCare's use is: helps control plaque that leads to gingivitis.

Cetylpyridinium chloride

0.1% concentrate / 0.05% post-dilution

Mechanism and biofilm behavior

Mao X, Auer DL, Buchalla W, Hiller K-A, Maisch T, Hellwig E, Al-Ahmad A, Cieplik F. Cetylpyridinium chloride: mechanism of action, antimicrobial efficacy in biofilms, and potential risks of resistance. Antimicrob Agents Chemother. 2020;64(8):e00576-20. doi:10.1128/AAC.00576-20

Establishes. A mechanistic review: the cationic structure adsorbs to the pellicle and to bacterial membranes, and the hydrophobic chain disrupts the membrane. Addresses efficacy in biofilm rather than in planktonic culture.

Aguilera FR, Viñas M, Sierra JM, Vinuesa T, Fernandez de Henestrosa AR, Furmanczyk M, Trullàs C, Jourdan E, López-López J, Jorba M. Substantivity of mouth-rinse formulations containing cetylpyridinium chloride and O-cymen-5-ol: a randomized-crossover trial. BMC Oral Health. 2022;22:646. doi:10.1186/s12903-022-02688-z

Establishes. Measured substantivity — CPC's retention in the oral cavity and continued antimicrobial activity after rinsing.

Plaque and gingivitis

Langa GPJ, Muniz FWMG, Costa RDSA, da Silveira TM, Rösing CK. The effect of cetylpyridinium chloride mouthrinse as adjunct to toothbrushing compared to placebo on interproximal plaque and gingival inflammation — a systematic review with meta-analyses. Clin Oral Investig. 2021;25(2):745-757. doi:10.1007/s00784-020-03661-2

Establishes. Eight randomized trials of at least six weeks. Every included study favored CPC rinse plus brushing over placebo plus brushing on at least one parameter.

Windhorst ER, Joosstens M, van der Sluijs E, Slot DE. The effect of cetylpyridinium chloride compared to chlorhexidine mouthwash on scores of plaque and gingivitis: a systematic review and meta-analyses. Int J Dent Hyg. 2025;23(4):665-681. doi:10.1111/idh.12916 · PMC12516004

Establishes. Fourteen papers and eighteen comparisons, covering CPC at 0.05%, 0.075% and 0.1%. Antiplaque efficacy was comparable to chlorhexidine.

Behavior on titanium surfaces

Sánchez MC, et al. Response to antiseptic agents of periodontal pathogens in in vitro biofilms on titanium and zirconium surfaces. Dent Mater. 2017;33(4):446-453. PMID 28237092

Establishes. Multispecies biofilms grown on SLA titanium and on zirconia. A. actinomycetemcomitans, P. gingivalis and F. nucleatum responded similarly on both surfaces despite structural differences between the biofilm communities.

Pulcini A, Bollaín J, Sanz-Sánchez I, Figuero E, Alonso B, Sanz M, Herrera D. Clinical effects of the adjunctive use of a 0.03% chlorhexidine and 0.05% cetylpyridinium chloride mouth rinse in the management of peri-implant diseases: a randomized clinical trial. J Clin Periodontol. 2019;46(3):342-353. doi:10.1111/jcpe.13088 · PMID 30779246

Establishes. A twelve-month double-blind randomized trial of a twice-daily rinse used adjunctively to professional and patient-administered mechanical plaque removal.

Zinc citrate

0.40% concentrate / 0.20% post-dilution

Stewart B, García-Godoy B, Mateo LR, Noboa J, Elias-Boneta AR. Mouthwash containing cetylpyridinium chloride and zinc lactate shows enhanced antiplaque and antigingivitis efficacy. Compend Contin Educ Dent. 2025;46(2). compendiumlive.com

Establishes. A Phase III examiner-blind parallel-group trial, 116 participants over six weeks. Mouthwash combining CPC with zinc outperformed CPC alone across plaque and gingivitis indices.

Adams SE, Cawley AK, Arnold D, Hoptroff MJ, Slomka V, Matheson JR, Marriott RE, Gemmell MR, Marsh PD. A randomised, double-blind clinical study into the effect of zinc citrate trihydrate toothpaste on oral plaque microbiome ecology and function. Sci Rep. 2025;15(1):8136. doi:10.1038/s41598-025-92545-0

Establishes. The closest published work to this salt form. 115 participants over six weeks; zinc citrate shifted both the composition and the metabolic function of the plaque microbiome.

Paiwand S, Schäfer S, Kopp A, Beikler T, Fiedler I, Gosau M, Fuest S, Smeets R. Antibacterial potential of silver and zinc loaded plasma-electrolytic oxidation coatings for dental titanium implants. Int J Implant Dent. 2025;11(1):12. doi:10.1186/s40729-025-00595-w

Establishes. Zinc's antibacterial activity against anaerobic organisms on titanium surfaces specifically.

Young A, Jonski G, Rölla G. Inhibition of orally produced volatile sulfur compounds by zinc, chlorhexidine or cetylpyridinium chloride — effect of concentration. Eur J Oral Sci. 2003;111(5):400-404. PMID 12974683 · doi:10.1034/j.1600-0722.2003.00063.x

Establishes. Dose- and time-dependent suppression of volatile sulfur compounds by zinc.

Xylitol

4.00% concentrate / 2.00% post-dilution

No literature is cited for xylitol here, and that is deliberate. The published work associating xylitol with reduced plaque studies chewing gum, at substantially higher doses and with repeated daily exposure; xylitol candies, by contrast, showed no effect on plaque. That evidence does not transfer to a diluted solution passing through an irrigator in a matter of seconds. Xylitol is in this formula for formulation reasons, not antimicrobial ones, and citing the gum literature here would imply more than the evidence supports.

Hypromellose (HPMC)

0.10% concentrate / 0.05% post-dilution

Mašková E, Kubová K, Raimi-Abraham BT, Vllasaliu D, Vohlídalová E, Turánek J, Mašek J. Hypromellose — a traditional pharmaceutical excipient with modern applications in oral and oromucosal drug delivery. J Control Release. 2020;324:695-727. doi:10.1016/j.jconrel.2020.05.045

Establishes. A review of hypromellose's mucoadhesive properties and its established role in oromucosal delivery systems, where modifying the rheology of a formulation prolongs its retention at the site of application.

Each ingredient in Implant ProCare is individually well characterized in the published literature. What the product contributes is combining them in a format built for irrigation around implants.

Samples and practice ordering

We can provide evaluation samples and chairside patient handouts to licensed dental practices. Email info@implantprocare.com from your practice domain with your name, license state, practice name, and shipping address.

Disclosures

Implant ProCare is a product of ANew32 OCP LLC. Dr. Kyle McGill, DDS, is the founder and owner of ANew32 OCP LLC and has a financial interest in the product.

Implant ProCare is an over-the-counter antigingivitis/antiplaque oral rinse. It is not indicated to treat, cure, or prevent peri-implant mucositis, peri-implantitis, periodontitis, or any other disease or condition, and no such claim is made. It is not a substitute for professional care or for a patient's maintenance interval.